Coleus barbatus was first described by Henry Cranke Andrews in 1810 as Plectranthus barbatus. Forskolin has also been used to treat heart, blood, and circulation conditions, and cancers. Experimental studies on various cancer cell lines have shown synergistic effects of forskolin in upregulating cellular responses.Lekmine 2008, Watanabe 2004, Watanabe 2005, Tong 2004, Li 2006, Kim 2004 A protective effect against ionizing radiationSolovjeva 2009 and UBV-induced apoptosisPasseron 2009 has been shown in vitro. Dosages of Forskolin Should Be Given As Follows: Oral. mô tả khoa học đầu tiên năm 1897. It has aromatic green leaves that grow off erect stems, and can reach heights of 2 feet. Adverse events were not reported.Huerta 2010, González-Sánchez 2006 Colforsin has also been evaluated as a bronchodilator in a limited number of studies.Wajima 2002, Wajima 2003, Bauer 1993, Studies in animals have shown various effects of forskolin, including induction of melatonin production in the pineal glands, increased melanin in hair follicles leading to an increase in pigmentation, increased hair growth, and a protective effect against ultraviolet B light (UBV)-induced apoptosis.Alasbahi 2010, Chen 2009, Lekmine 2008, Passeron 2009, Case reports exist showing improvement of psoriatic symptoms and a decrease in erythema in patients with hyperplastic skin disorders.Alasbahi 2010, Oral forskolin has been studied using 10 mg daily over 2 to 6 months.Huerta 2010, González-Sánchez 2006, 250 mg of a 10% forskolin extract twice daily for 12 weeks has been studied.Godard 2005, Henderson 2005, Information regarding safety and efficacy in pregnancy and lactation is lacking. Oral forskolin performed better than sodium chromoglycate in preventing asthma attacks in children and adults with mild/moderate persistent asthma, while inhaled forskolin was not superior to beclomethasone in lung function improvement. Content of the essential oil depends on location and time of harvesting, and mainly consists of mono- and sesquiterpenes. An increase in serum testosterone was also demonstrated. Coleus forskohlii is the only known natural source of the unique adenylate cyclase activating phytonutrient, forskolin3. Available for Android and iOS devices. This information is not specific medical advice and does not replace information you receive from your health care provider. 25 The antiproliferative activity of 13-epi-sclareol is comparable to … No changes in various metabolic markers or laboratory indices were found, except for changes in white blood count, serum calcium, ALT, and uric acid levels.Henderson 2005, Forskolin has been used in animal and limited clinical studies in glaucoma, with only temporary effects reported.Alasbahi 2010, In addition to smooth muscle relaxant properties, forskolin also exerts activity on inflammatory mediators, including interleukins and histamine, and on calcium ion influx, leading to its evaluation in asthma.Alasbahi 2010, Huerta 2010, In guinea pigs, forskolin blocked bronchospasm caused by inflammatory mediators (histamine, leukotriene-4) and antigens. The main bioactive ingredient in Coleus forskohlii is called forskolin. edulis. , A preliminary study of the tribe Ocimeae in 2004 showed that the subtribe Plectranthinae was monophyletic, with two main clades: one containing the type species of Coleus and including Solenostemon, the other containing the type species of Plectranthus along with some other genera, so that Plectranthus when broadly defined was not monophyletic. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Synonyms include Plectranthus forskalaei, Plectranthus forskohlii, Plectranthus kilimandschari, Plectranthus grandis, Coleus forskohlii, Coleus barbatus, and Coleus coerulescens.The plant is native to subtropical and tropical regions of India and East Africa, grows to a height of 60 cm, and has large, soft leaves. Equilabium was segregated from Plectranthus, after phylogenetic studies supported its recognition as a phylogenetically distinct genus. In India, the plant is cultivated for use in pickles.Alasbahi 2010, Insel 2003, Alasbahi 2010, The main constituents of P. barbatus are the diterpenoids and essential oil. Forskolin should be avoided in patients with polycystic kidney disease. Europe Coleus Forskohlii Extract Market 2020 is Evolving Rapidly with Economic Growth, Demand, and Forthcoming … Today, Coleus forskohlii is used as a fat burning supplement. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age. ( syns more than 24,000 prescription drugs, over-the-counter medicines and natural products tachycardia. 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